Seric anti-toxoid tetanus and diphtheria G immunoglobulins in patients treated in the immunogenetics Service

Authors

Keywords:

antibodies, immunoglobulin G, tetanus toxoid, diptheria toxoid, vaccines

Abstract

Introduction: The evaluation of antibodies against vaccine antigens allows, at the individual level, to evaluate the competence of the immune system and to know the protection that this individual presents against a certain infectious disease.

Objective: To evaluate the concentrations of anti-tetanus and diphtheric immunoglobulins G in patients treated at immunogenetics service.

Methods: A descriptive study was carried out on 677 patients from specialized immunogenetics clinics of the National Center for Medical Genetics. 457 women and 220 men aged between 1 and 80 years. Serum immunoglobulin G concentrations were determined by an indirect immunozyme assay. Geometric mean concentrations were calculated and antibody responses were classified into unreliable protection, reliable protection, and long-term reliable protection. A paired analysis of individual titers for each antitoxin was performed.

Results: For tetanus toxoid 60.11% of the cases, presented reliable long-term protection and geometric mean concentrations exceeded 1 IU/mL in all age groups. For diphtheria toxoid the long-term protection was 4. 14 % and the geometric mean was less than 0.4 IU/mL. Coupled analysis of individual concentrations for both toxoids showed, in all age groups and sex, a significantly lower concentration of diphtheria antitoxoid.

Conclusions: Low levels of reliable long-term protection against diphtheria pose a risk for the development of cases of this disease and support the need for future re-immunizations.

 

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Published

2023-12-22

How to Cite

1.
Rodríguez Pelier CV, Zúñiga Rosales Y, Torres Rives B, Martínez Perera A, Villegas Valverde CA, Cruz Arbelo D. Seric anti-toxoid tetanus and diphtheria G immunoglobulins in patients treated in the immunogenetics Service. revgencom [Internet]. 2023 Dec. 22 [cited 2025 Jul. 7];14(2). Available from: https://revgenetica.sld.cu/index.php/gen/article/view/159

Issue

Vol. 14 No. 2 (2022): SEPTIEMBRE-DICIEMBRE

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