Relation of HLA-DRB1 alleles with therapeutic response in rheumatoid arthritis. A systematic review
Keywords:
rheumatoid arthritis, HLA antigens, drug therapy, systematic review.Abstract
Introduction: The search for predictors of prognosis and therapeutic response in rheumatoid arthritis is essential to personalize therapy in these patients. Research on the contribution of the HLA-DRB1 allele may open up new opportunities to improve the diagnosis and therapy of the disease.
Objective: To describe recent studies that analyse the relationship of HLA-DRB1 alleles with the therapeutic response of rheumatoid arthritis patients treated with conventional or biological drugs.
Methods: A qualitative systematic review of the last ten years 2011-2021 was carried out in the Medline and Cochrane databases.
Results: The electronic search in Medline showed 200 articles. A total of 194 articles did not meet the inclusion criteria and were excluded, thus, 6 articles were included in the study. The electronic Cochrane search showed 25 articles and 23 were excluded, including only 2 articles matching the Medline search.
Conclusions: The HLA-DRB1 gene will be essential for the development of personalized diagnosis and treatment protocols in patients with rheumatoid arthritis. The studies included in this systematic review support the clinical therapeutic importance of the HLA-DRB1 alleles in positions 11, 70-74, as a biomarker of the therapeutic response of patients with rheumatoid arthritis.
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